The working of Blink-Con, a framework for intelligent vision directed mobilization of onscreen mouse-cursor, without engaging any auxiliary assistance, is illustrated in this paper. Blink-Con is framed keeping in mind the corporal accessibility limitations of a specially abled person in operating, controlling and interacting with physical devices. In this work the system explored are technically dominated in color spaces, precise ROI detection, closed loop sequential interaction and eventually a system gets constructed and attained where the GUI onscreen pointer (mouse cursor) gets directed by interpreting significant eye gaze and blink. The algorithm for eye blink detection from 2-D image feed been classified in two major step for accomplishing a heuristic based region of interest (ROI) identification and tracking the ROI for rapid detection of volunteered blinks. The sequence of volunteered blinks are taken as trigger of robust mouse mobilization function input, that results in highly optimized smooth mouse-travel, divulging an adaptable mouse control performance with only eye blink. The experimental results are favorable to the system viability for multi facet use of the algorithms.